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Evolution of mammalian longevity: age-related increase in autophagy in bats compared to other mammals.

ABSTRACT: Autophagy maintains cellular homeostasis and its dysfunction has been implicated in aging. Bats are the longest-lived mammals for their size, but the molecular mechanisms underlying their extended healthspan are not well understood. Here, drawing on >8 years of mark-recapture field studies, we report the first longitudinal analysis of autophagy regulation in bats. Mining of published population level aging blood transcriptomes (M. myotis, mouse and human) highlighted a unique increase of autophagy related transcripts with age in bats, but not in other mammals. This bat-specific increase in autophagy transcripts was recapitulated by the western blot determination of the autophagy marker, LC3II/I ratio, in skin primary fibroblasts (Myotis myotis, Pipistrellus kuhlii, mouse), that also showed an increase with age in both bat species. Further phylogenomic selection pressure analyses across eutherian mammals (n=70 taxa; 274 genes) uncovered 10 autophagy-associated genes under selective pressure in bat lineages. These molecular adaptations potentially mediate the exceptional age-related increase of autophagy signalling in bats, which may contribute to their longer healthspans.

SUBMITTER: Kacprzyk J

PROVIDER: S-EPMC8034928 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Genome Methylation Predicts Age and Longevity of Bats

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Author Correction: DNA methylation predicts age and provides insight into exceptional longevity of bats.

Project description: Not available

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