Preschoolers have better long-term memory for rhyming text than adults.
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ABSTRACT:
SUBMITTER: Kiraly I
PROVIDER: S-EPMC8035052 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:BackgroundSustained environmental enrichment (EE) through a variety of leisure activities may decrease the risk of developing Alzheimer's disease. This cross-sectional cohort study investigated the association between long-term EE in young adulthood through middle life and microstructure of fiber tracts associated with the memory system in older adults.MethodsN = 201 cognitively unimpaired participants (≥ 60 years of age) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) baseline cohort were included. Two groups of participants with higher (n = 104) or lower (n = 97) long-term EE were identified, using the self-reported frequency of diverse physical, intellectual, and social leisure activities between the ages 13 to 65. White matter (WM) microstructure was measured by fractional anisotropy (FA) and mean diffusivity (MD) in the fornix, uncinate fasciculus, and parahippocampal cingulum using diffusion tensor imaging. Long-term EE groups (lower/higher) were compared with adjustment for potential confounders, such as education, crystallized intelligence, and socio-economic status.ResultsReported participation in higher long-term EE was associated with greater fornix microstructure, as indicated by higher FA (standardized β = 0.117, p = 0.033) and lower MD (β = -0.147, p = 0.015). Greater fornix microstructure was indirectly associated (FA: unstandardized B = 0.619, p = 0.038; MD: B = -0.035, p = 0.026) with better memory function through higher long-term EE. No significant effects were found for the other WM tracts.ConclusionOur findings suggest that sustained participation in a greater variety of leisure activities relates to preserved WM microstructure in the memory system in older adults. This could be facilitated by the multimodal stimulation associated with the engagement in a physically, intellectually, and socially enriched lifestyle. Longitudinal studies will be needed to support this assumption.
| S-EPMC10498282 | biostudies-literature
Project description:This study describes a functional magnetic resonance imaging study of humans engaged in long-term memory (LTM) and working memory tasks. A pattern classifier learned to identify patterns of brain activity associated with viewing and making judgments about three categories of pictures (famous people, famous locations, and common objects). The evaluation of these stimuli relied on perception and long-term semantic and/or episodic memories. We investigated whether this classifier could successfully decode brain activity from a subsequent delayed paired-associate recognition working memory task that required the short-term retention of the same stimuli. We reasoned that the LTM-trained classifier would be able to decode delay-period activity only if that activity reflected, to some extent, the temporary activation of LTM. Our results demonstrated successful decoding: delay-period activity from a distributed network of brain regions matched learned patterns of activity for task-relevant stimuli to a greater extent than for task-irrelevant stimuli. In varying degrees throughout the delay, activity reflected the target (a retrospective code) and its associate (a prospective code) with considerable variability among subjects. Although prefrontal cortex (PFC) demonstrated category-specific patterns of activity during the LTM task, these patterns were not reinstated in PFC during the working memory task. We conclude that the short-term retention of information can be supported by the temporary reactivation of LTM representations.
| S-EPMC2699183 | biostudies-other
Project description:Increasing access to media in the 21st century has led to a rapid rise in the prevalence of media multitasking (simultaneous use of multiple media streams). Such behavior is associated with various cognitive differences, such as difficulty filtering distracting information and increased trait impulsivity. Given the rise in media multitasking by children, adolescents, and adults, a full understanding of the cognitive profile of media multitaskers is imperative. Here we investigated the relationship between chronic media multitasking and working memory (WM) and long-term memory (LTM) performance. Four key findings are reported (1) heavy media multitaskers (HMMs) exhibited lower WM performance, regardless of whether external distraction was present or absent; (2) lower performance on multiple WM tasks predicted lower LTM performance; (3) media multitasking-related differences in memory reflected differences in discriminability rather than decision bias; and (4) attentional impulsivity correlated with media multitasking behavior and reduced WM performance. These findings suggest that chronic media multitasking is associated with a wider attentional scope/higher attentional impulsivity, which may allow goal-irrelevant information to compete with goal-relevant information. As a consequence, heavy media multitaskers are able to hold fewer or less precise goal-relevant representations in WM. HMMs' wider attentional scope, combined with their diminished WM performance, propagates forward to yield lower LTM performance. As such, chronic media multitasking is associated with a reduced ability to draw on the past--be it very recent or more remote--to inform present behavior.
| S-EPMC4733435 | biostudies-other
Project description:Long-term memory (LTM) associations appear as important to cognition as single memory contents. Previous studies on updating development have focused on cognitive processes and components, whereas our investigation examines how contents, associated with different LTM strength (strong or weak), might be differentially updated at different ages. To this end, we manipulated association strength of information given at encoding, in order to focus on updating pre-existing LTM associations; specifically, associations for letters. In particular, we controlled for letters usage frequency at the sub-lexical level. We used a task where we dissociated inhibition online (i.e., RTs for updating and controlling inhibition from the same set) and offline (i.e., RTs for controlling inhibition from previously updated sets). Mixed-effect analyses were conducted and showed a substantial behavioural cost when strong associations had to be dismantled online (i.e., longer RTs), compared to weak ones; here, in primary school age children. Interestingly, this effect was independent of age; in fact, children from 7-8 to 9-10 years were comparably sensitive to the strength of LTM associations in updating. However, older children were more effective in offline inhibitory control.
| S-EPMC6544283 | biostudies-literature
Project description:Antimicrobial peptides act as a host defense mechanism and regulate the commensal microbiome. To obtain a comprehensive view of genes contributing to long-term memory we performed mRNA sequencing from single Drosophila heads following behavioral training that produces long-lasting memory. Surprisingly, we found that Diptericin B, an immune peptide with antimicrobial activity, is upregulated following behavioral training. Deletion and knock down experiments revealed that Diptericin B and another immune peptide, Gram-Negative Bacteria Binding Protein like 3, regulate long-term but not short-term memory or instinctive behavior in Drosophila. Interestingly, removal of DptB in the head fat body and GNBP-like3 in neurons results in memory deficit. That putative antimicrobial peptides influence memory provides an example of how some immune peptides may have been repurposed to influence the function of nervous system.
| S-EPMC6224176 | biostudies-literature
Project description:This SuperSeries is composed of the SubSeries listed below.
2018-09-15 | GSE113347 | GEO
Project description:The NR2A:NR2B subunit ratio of the NMDA receptors is widely known to increase in the brain from postnatal development to sexual maturity and to aging, yet its impact on memory function remains speculative. We have generated forebrain-specific NR2A overexpression transgenic mice and show that these mice had normal basic behaviors and short-term memory, but exhibited broad long-term memory deficits as revealed by several behavioral paradigms. Surprisingly, increased NR2A expression did not affect 1-Hz-induced long-term depression (LTD) or 100 Hz-induced long-term potentiation (LTP) in the CA1 region of the hippocampus, but selectively abolished LTD responses in the 3-5 Hz frequency range. Our results demonstrate that the increased NR2A:NR2B ratio is a critical genetic factor in constraining long-term memory in the adult brain. We postulate that LTD-like process underlies post-learning information sculpting, a novel and essential consolidation step in transforming new information into long-term memory.
| S-EPMC3539144 | biostudies-other
Project description:Initially inspired by the Atkinson and Shiffrin model, researchers have spent a half century investigating whether actively maintaining an item in working memory (WM) leads to improved subsequent long-term memory (LTM). Empirical results have been inconsistent, and thus the answer to the question remains unclear. We present evidence from 13 new experiments as well as a meta-analysis of 61 published experiments. Both the new experiments and meta-analysis show clear evidence that increased WM maintenance of a stimulus leads to superior recognition for that stimulus in subsequent LTM tests. This effect appears robust across a variety of experimental design parameters, suggesting that the variability in prior results in the literature is probably due to low power and random chance. The results support theories on which there is a close link between WM and LTM mechanisms, while challenging claims that this relationship is specific to verbal memory and evolved to support language acquisition.
| S-EPMC6663308 | biostudies-literature
Project description:Long term temporal correlations frequently appear at many levels of neural activity. We show that when such correlations appear in isolated neurons, they indicate the existence of slow underlying processes and lead to explicit conditions on the dynamics of these processes. Moreover, although these slow processes can potentially store information for long times, we demonstrate that this does not imply that the neuron possesses a long memory of its input, even if these processes are bidirectionally coupled with neuronal response. We derive these results for a broad class of biophysical neuron models, and then fit a specific model to recent experiments. The model reproduces the experimental results, exhibiting long term (days-long) correlations due to the interaction between slow variables and internal fluctuations. However, its memory of the input decays on a timescale of minutes. We suggest experiments to test these predictions directly.
| S-EPMC3978321 | biostudies-literature
Project description:BACKGROUND:There have been reports of long-term subjective memory worsening after electroconvulsive therapy (ECT). AIMS:To study the prevalence and risk factors of long-term subjective memory worsening among patients receiving ECT in routine clinical practice. METHOD:Patients (n = 535, of whom 277 were included in the final analysis) were recruited from eight Swedish hospitals. Participants' subjective memory impairment was assessed before ECT and a median of 73 days after ECT using the memory item from the Comprehensive Psychopathological Rating Scale. Participants also rated their pre-ECT expectations and post-ECT evaluations of the effect of ECT on memory on a 7-point scale. We used ordinal regression to identify variables associated with subjective memory worsening and negative evaluations of the effect of ECT on memory. RESULTS:Comparisons of pre- and post-ECT assessments showed that subjective memory worsened in 16.2% of participants, remained unchanged in 52.3% and improved in 31.4%. By contrast, when asked to evaluate the effect of ECT on memory after treatment 54.6% reported a negative effect. Subjective memory worsening was associated with negative expectations before ECT, younger age and shorter duration of follow-up. CONCLUSIONS:Although subjective memory improved more often than it worsened when assessed before and after ECT, a majority of patients reported that ECT had negative effects on their memory when retrospectively asked how ECT had affected it. This might suggest that some patients attribute pre-existing subjective memory impairment to ECT. Clinicians should be aware that negative expectations are associated with subjective worsening of memory after ECT.
| S-EPMC7176828 | biostudies-literature