Ontology highlight
ABSTRACT:
SUBMITTER: He YJ
PROVIDER: S-EPMC8035317 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
He Yusheng J YJ Santana Martin F MF Staneviciute Austeja A Pimentel Marja B MB Yang Feipeng F Goes Jacob J Kawaji Keigo K Vaicik Marcella K MK Abdulhadi Rayan R Hibino Narutoshi N Papavasiliou Georgia G
Advanced healthcare materials 20210129 7
Gradients in mechanical properties, physical architecture and biochemical composition exist in a variety of complex tissues, yet 3D in vitro models that enable investigation of these cues on cellular processes, especially those contributing to vascularization of engineered tissues are limited. Here, a photopolymerization approach to create cell-laden hydrogel biomaterials with decoupled and combined gradients in modulus, immobilized cell adhesive peptide (RGD) concentration, and proteolytic degr ...[more]