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Recent Advances in Nanotechnology with Nano-Phytochemicals: Molecular Mechanisms and Clinical Implications in Cancer Progression.

ABSTRACT: Biocompatible nanoparticles (NPs) containing polymers, lipids (liposomes and micelles), dendrimers, ferritin, carbon nanotubes, quantum dots, ceramic, magnetic materials, and gold/silver have contributed to imaging diagnosis and targeted cancer therapy. However, only some NP drugs, including Doxil^® (liposome-encapsulated doxorubicin), Abraxane^® (albumin-bound paclitaxel), and Oncaspar^® (PEG-Asparaginase), have emerged on the pharmaceutical market to date. By contrast, several phytochemicals that were found to be effective in cultured cancer cells and animal studies have not shown significant efficacy in humans due to poor bioavailability and absorption, rapid clearance, resistance, and toxicity. Research to overcome these drawbacks by using phytochemical NPs remains in the early stages of clinical translation. Thus, in the current review, we discuss the progress in nanotechnology, research milestones, the molecular mechanisms of phytochemicals encapsulated in NPs, and clinical implications. Several challenges that must be overcome and future research perspectives are also described.

SUBMITTER: Kim B

PROVIDER: S-EPMC8036762 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Temozolomide: An Updated Overview of Resistance Mechanisms, Nanotechnology Advances and Clinical Applications.

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Recent Advances in the Molecular Mechanisms Underlying Pyroptosis in Sepsis.

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| S-EPMC5863298 | biostudies-other

Fibrolamellar Carcinoma: Recent Advances and Unresolved Questions on the Molecular Mechanisms.

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| S-EPMC6020845 | biostudies-literature

Clinical implications of recent advances in primary open-angle glaucoma genetics.

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Recent Advances in Molecular Mechanisms of the NKG2D Pathway in Hepatocellular Carcinoma.

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| S-EPMC7094213 | biostudies-literature

Recent advances in the molecular mechanisms of Mayer-Rokitansky-Kuster-Hauser syndrome.

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| S-EPMC10709101 | biostudies-literature

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Biosynthesis of polyunsaturated fatty acids in marine invertebrates: recent advances in molecular mechanisms.

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| S-EPMC3826146 | biostudies-literature

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