Ontology highlight
ABSTRACT:
SUBMITTER: Piccinin E
PROVIDER: S-EPMC8036867 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Piccinin Elena E Sardanelli Anna Maria AM Seibel Peter P Moschetta Antonio A Cocco Tiziana T Villani Gaetano G
International journal of molecular sciences 20210328 7
Parkinson's disease is one of the most common neurodegenerative disorders worldwide, characterized by a progressive loss of dopaminergic neurons mainly localized in the <i>substantia nigra pars compacta</i>. In recent years, the detailed analyses of both genetic and idiopathic forms of the disease have led to a better understanding of the molecular and cellular pathways involved in PD, pointing to the centrality of mitochondrial dysfunctions in the pathogenic process. Failure of mitochondrial qu ...[more]