Unknown

Dataset Information

0

Apoptosis-Inducing TNF Superfamily Ligands for Cancer Therapy.


ABSTRACT: Cancer is a complex disease with apoptosis evasion as one of its hallmarks; therefore, apoptosis induction in transformed cells seems a promising approach as a cancer treatment. TNF apoptosis-inducing ligands, which are naturally present in the body and possess tumoricidal activity, are attractive candidates. The most studied proteins are TNF-α, FasL, and TNF-related apoptosis-inducing ligand (TRAIL). Over the years, different recombinant TNF family-derived apoptosis-inducing ligands and agonists have been designed. Their stability, specificity, and half-life have been improved because most of the TNF ligands have the disadvantages of having a short half-life and affinity to more than one receptor. Here, we review the outlook on apoptosis-inducing ligands as cancer treatments in diverse preclinical and clinical stages and summarize strategies of overcoming their natural limitations to improve their effectiveness.

SUBMITTER: Diaz Arguello OA 

PROVIDER: S-EPMC8036978 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC3967553 | biostudies-literature
| S-EPMC8781899 | biostudies-literature
| S-EPMC8983021 | biostudies-literature
| S-EPMC8473884 | biostudies-literature
| S-EPMC5877576 | biostudies-other
| S-EPMC5564678 | biostudies-literature
| S-EPMC5481552 | biostudies-literature
| S-EPMC2646499 | biostudies-literature
| S-EPMC4600855 | biostudies-literature
| S-EPMC3629958 | biostudies-literature