Unknown

Dataset Information

0

Facile Synthesis of Saikosaponins.


ABSTRACT: Saikosaponin A (SSa) and D (SSd) are typical oleanane-type saponins featuring a unique 13,28-epoxy-ether moiety at D ring of the aglycones, which exhibit a wide range of biological and pharmacological activities. Herein, we report the first synthesis of saikosaponin A/D (1-2) and their natural congeners, including prosaikosaponin F (3), G (4), saikosaponin Y (5), prosaikogenin (6), and clinoposaponin I (7). The present synthesis features ready preparation of the aglycones of high oxidation state from oleanolic acid, regioselective glycosylation to construct the β-(1→3)-linked disaccharide fragment, and efficient gold(I)-catalyzed glycosylation to install the glycans on to the aglycones.

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8037928 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC4142627 | biostudies-literature
| S-EPMC4715893 | biostudies-literature
| S-EPMC6050526 | biostudies-literature
| S-EPMC7022980 | biostudies-literature
| S-EPMC7034983 | biostudies-literature
| S-EPMC2504466 | biostudies-literature
| S-EPMC7179490 | biostudies-literature
| S-EPMC4472006 | biostudies-literature
| S-EPMC3070263 | biostudies-literature
| S-EPMC6097902 | biostudies-literature