Ontology highlight
ABSTRACT:
SUBMITTER: Kumar S
PROVIDER: S-EPMC8040494 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Kumar Suresh S De Souza Rosemarie R Nadkar Milind M Guleria Randeep R Trikha Anjan A Joshi Shashank R SR Loganathan Subramanian S Vaidyanathan Sivakumar S Marwah Ashwani A Athalye Sandeep N SN
Expert opinion on biological therapy 20210409 5
<b>Objective</b>: Efficacy and safety of Itolizumab, an immunomodulatory mAb, in treating moderate-to-severe acute respiratory distress syndrome (ARDS) due to cytokine release in COVID-19 patients was evaluated in a multi-centric, open-label, two-arm, controlled, randomized, phase-2 study.<b>Methods</b>: Patients were randomized (2:1) to Arm-A (best supportive care [BSC]+Itolizumab) and Arm-B (BSC). Primary outcome of interest was reduction in mortality 30-days after enrollment.<b>Results</b>: T ...[more]