The Complex Association Between Bariatric Surgery and Depression: a National Nested-Control Study.

ABSTRACT:

Background

Although bariatric surgery has been shown to reduce weight loss and obesity-related conditions, an improvement in depression remains unclear. The aim of this study was to determine whether bariatric surgery is associated with a resolution of depression, and the prevention of its onset.

Method

Patients with a BMI ≥ 30 kg/m² who had undergone bariatric surgery were identified from the Clinical Practice Research Datalink (CPRD), matched 5:1 to controls. Cox regression analysis was used to determine the risk of developing de novo depression. Kaplan-Meier analysis compared the proportion of patients with no further consultations related to depression between the two groups.

Results

In total, 3534 patients who underwent surgery, of which 2018 (57%) had

SUBMITTER: Arhi CS 

PROVIDER: S-EPMC8041688 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature