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Ultrafast light field tomography for snapshot transient and non-line-of-sight imaging.

ABSTRACT: Cameras with extreme speeds are enabling technologies in both fundamental and applied sciences. However, existing ultrafast cameras are incapable of coping with extended three-dimensional scenes and fall short for non-line-of-sight imaging, which requires a long sequence of time-resolved two-dimensional data. Current non-line-of-sight imagers, therefore, need to perform extensive scanning in the spatial and/or temporal dimension, restricting their use in imaging only static or slowly moving objects. To address these long-standing challenges, we present here ultrafast light field tomography (LIFT), a transient imaging strategy that offers a temporal sequence of over 1000 and enables highly efficient light field acquisition, allowing snapshot acquisition of the complete four-dimensional space and time. With LIFT, we demonstrated three-dimensional imaging of light in flight phenomena with a <10 picoseconds resolution and non-line-of-sight imaging at a 30 Hz video-rate. Furthermore, we showed how LIFT can benefit from deep learning for an improved and accelerated image formation. LIFT may facilitate broad adoption of time-resolved methods in various disciplines.

SUBMITTER: Feng X

PROVIDER: S-EPMC8041853 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:SignificanceLine-field confocal optical coherence tomography (LC-OCT) is a recently introduced high-resolution imaging modality based on a combination of low-coherence optical interferometry and reflectance confocal optical microscopy with line illumination and line detection. Capable of producing three-dimensional (3D) images of the skin with cellular resolution, in vivo, LC-OCT has been mainly applied in dermatology and dermo-cosmetology. The LC-OCT devices capable of acquiring 3D images reported so far are based on a Linnik interferometer using two identical microscope objectives. In this configuration, LC-OCT cannot be designed to be a very compact and light device, and the image acquisition speed is limited.AimThe objective of this work was to develop a more compact and lighter LC-OCT device that is capable of acquiring images faster without significant degradation of the resolution and with optimized detection sensitivity.ApproachWe developed an LC-OCT device based on a Mirau interferometer using a single objective. Dynamic adjustment of the camera frequency during the depth scan is implemented, using a faster camera and a more powerful light source. The reflectivity of the beam-splitter in the Mirau interferometer was optimized to maximize the detection sensitivity. A galvanometer scanner was incorporated into the device for scanning the illumination line laterally. A stack of adjacent B-scans, constituting a 3D image, can thus be acquired.ResultsThe device is able to acquire and display B-scans at 17 fps. 3D images with a quasi-isotropic resolution of ∼1.5 μm (1.3, 1.9, and 1.1 μm in the x , y, and z directions, respectively) over a field of 940 μm × 600 μm × 350 μm (x × y × z) can be obtained. 3D imaging of human skin at cellular resolution, in vivo, is reported.ConclusionsThe acquisition rate of the B-scans, at 17 fps, is unprecedented in LC-OCT. Compared with the conventional LC-OCT devices based on a Linnik interferometer, the reported Mirau-based LC-OCT device can acquire B-scans ∼2 times faster. With potential advantages in terms of compactness and weight, a Mirau-based device could easily be integrated into a smaller and lighter handheld probe for use by dermatologists in their daily medical practice.

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Ultrafast light field tomography for snapshot transient and non-line-of-sight imaging.

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