Cost-effectiveness analysis of alternative colorectal cancer screening strategies in high-risk individuals.

ABSTRACT:

Background and aims

Current guidelines recommend colonoscopy every 3-5 years for colorectal cancer (CRC) screening of individuals with a familial history of CRC. The objective of this study was to compare the cost effectiveness of screening alternatives in this population.

Methods

Eight screening strategies were compared with no screening: fecal immunochemical test (FIT), Stool DNA and blood-based screening every 2 years, colonoscopy, computed tomography colonography, colon capsules, and sigmoidoscopy every 5 years, and colonoscopy at 45 years followed, if negative, by FIT every 2 years. Screening test and procedures performance were obtained from the literature. A microsimulation model reproducing the natural history of CRC was used to estimate the cost (€2018) and e

SUBMITTER: Benamouzig R 

PROVIDER: S-EPMC8042553 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature