A new risk-stratification system for hepatoblastoma in children under six years old and the significance for prognosis evaluation-a 14-year retrospective study from a single center.

ABSTRACT:

Background

This study explores and analyzes the clinical characteristics and prognostic factors of hepatoblastoma (HB) in children under 6 years old and establishes a new risk-stratification system for individualized therapy.

Methods

The clinical data of 382 pediatric patients under 6 years old (231 males and 151 females) who had been diagnosed with HB by pathology between May 2005 and May 2019 were collected. By analyzing the risk factors influencing the survival rate of patients with HB, a new risk-stratification system was established, and it was compared with previous risk-stratification systems by a receiver operating characteristic (ROC) curve.

Results

(1) According to a Kaplan-Meier survival analysis, the one-year, three-year, and five-year overall survival (OS

SUBMITTER: Zhi T 

PROVIDER: S-EPMC8042704 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature