Ontology highlight
ABSTRACT:
SUBMITTER: Alavi Darazam I
PROVIDER: S-EPMC8044200 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Alavi Darazam Ilad I Shokouhi Shervin S Pourhoseingholi Mohamad Amin MA Naghibi Irvani Seyed Sina SS Mokhtari Majid M Shabani Minoosh M Amirdosara Mahdi M Torabinavid Parham P Golmohammadi Maryam M Hashemi SayedPayam S Azimi Arsalan A Jafarazadeh Maivan Mohammad Hossein MH Rezaei Omidvar O Zali Alireza A Hajiesmaeili Mohammadreza M Shabanpour Dehbsneh Hadiseh H Hoseyni Kusha Akram A Taleb Shoushtari Maryam M Khalili Negar N Soleymaninia Azam A Gachkar Latif L Khoshkar Ali A
Scientific reports 20210413 1
Type 1 Interferons (IFNs) have been associated with positive effects on Coronaviruses. Previous studies point towards the superior potency of IFNβ compared to IFNα against viral infections. We conducted a three-armed, individually-randomized, open-label, controlled trial of IFNβ1a and IFNβ1b, comparing them against each other and a control group. Patients were randomly assigned in a 1:1:1 ratio to IFNβ1a (subcutaneous injections of 12,000 IU on days 1, 3, 6), IFNβ1b (subcutaneous injections of 8 ...[more]