Ontology highlight
ABSTRACT:
SUBMITTER: Vizan P
PROVIDER: S-EPMC8044520 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Vizán Pedro P Di Croce Luciano L Aranda Sergi S
Frontiers in cell and developmental biology 20210331
Adenosylhomocysteinase (AHCY) is a unique enzyme and one of the most conserved proteins in living organisms. AHCY catalyzes the reversible break of <i>S</i>-adenosylhomocysteine (SAH), the by-product and a potent inhibitor of methyltransferases activity. In mammals, AHCY is the only enzyme capable of performing this reaction. Controlled subcellular localization of AHCY is believed to facilitate local transmethylation reactions, by removing excess of SAH. Accordingly, AHCY is recruited to chromat ...[more]