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Sacraoxides A-G, Bioactive Cembranoids from Gum Resin of Boswellia sacra.

ABSTRACT: Seven undescribed cembranoids, sacraoxides A-G (1, 3-8) were isolated from the gum resin of Boswellia sacra. Their structures were elucidated by extensive physicochemical and spectroscopic analysis, as well as ECD calculation, modified Mosher's method and X-ray diffraction crystallography. Compounds 6 and 7 exhibited inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide in RAW264.7 cells with IC₅₀ values of 24.9 ± 1.7 and 36.4 ± 2.9 μM.

SUBMITTER: Zhang B

PROVIDER: S-EPMC8044883 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Sacraoxides A-G, Bioactive Cembranoids from Gum Resin of Boswellia sacra.

Zhang Bingyang B Liu Di D Ji Wenyue W Otsuki Kouharu K Higai Koji K Zhao Feng F Li Wei W Koike Kazuo K Qiu Feng F

Frontiers in chemistry 20210330

Seven undescribed cembranoids, sacraoxides A-G (1, 3-8) were isolated from the gum resin of Boswellia sacra. Their structures were elucidated by extensive physicochemical and spectroscopic analysis, as well as ECD calculation, modified Mosher's method and X-ray diffraction crystallography. Compounds 6 and 7 exhibited inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide in RAW264.7 cells with IC50 values of 24.9 ± 1.7 an ...[more]

PMID: 33869144

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