Ontology highlight
ABSTRACT:
SUBMITTER: Roussel M
PROVIDER: S-EPMC8045516 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Roussel Mikaël M Le Kieu-Suong KS Granier Clémence C Llamas Gutierrez Francisco F Foucher Etienne E Le Gallou Simon S Pangault Céline C Xerri Luc L Launay Vincent V Lamy Thierry T Tartour Eric E Olive Daniel D Fest Thierry T
Blood advances 20210401 7
In diffuse large B-cell lymphoma (DLBCL), tumor-infiltrating T lymphocytes (TILs) are involved in therapeutic responses. However, tumor-specific TILs can be dysfunctional, with impaired effector functions. Various mechanisms are involved in this exhaustion, and the increased expression of programmed cell death receptor 1 (PD1) and TIM3 on dysfunctional cells suggests their involvement. However, conflicting data have been published regarding their expression or coexpression in DLBCL. We evaluated ...[more]