Ontology highlight
ABSTRACT:
SUBMITTER: Lanzoni G
PROVIDER: S-EPMC8046040 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Lanzoni Giacomo G Linetsky Elina E Correa Diego D Messinger Cayetano Shari S Alvarez Roger A RA Kouroupis Dimitrios D Alvarez Gil Ana A Poggioli Raffaella R Ruiz Phillip P Marttos Antonio C AC Hirani Khemraj K Bell Crystal A CA Kusack Halina H Rafkin Lisa L Baidal David D Pastewski Andrew A Gawri Kunal K Leñero Clarissa C Mantero Alejandro M A AMA Metalonis Sarah W SW Wang Xiaojing X Roque Luis L Masters Burlett B Kenyon Norma S NS Ginzburg Enrique E Xu Xiumin X Tan Jianming J Caplan Arnold I AI Glassberg Marilyn K MK Alejandro Rodolfo R Ricordi Camillo C
Stem cells translational medicine 20210105 5
Acute respiratory distress syndrome (ARDS) in COVID-19 is associated with high mortality. Mesenchymal stem cells are known to exert immunomodulatory and anti-inflammatory effects and could yield beneficial effects in COVID-19 ARDS. The objective of this study was to determine safety and explore efficacy of umbilical cord mesenchymal stem cell (UC-MSC) infusions in subjects with COVID-19 ARDS. A double-blind, phase 1/2a, randomized, controlled trial was performed. Randomization and stratification ...[more]