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The variability of MR axon radii estimates in the human white matter.


ABSTRACT: The noninvasive quantification of axonal morphology is an exciting avenue for gaining understanding of the function and structure of the central nervous system. Accurate non-invasive mapping of micron-sized axon radii using commonly applied neuroimaging techniques, that is, diffusion-weighted MRI, has been bolstered by recent hardware developments, specifically MR gradient design. Here the whole brain characterization of the effective MR axon radius is presented and the inter- and intra-scanner test-retest repeatability and reproducibility are evaluated to promote the further development of the effective MR axon radius as a neuroimaging biomarker. A coefficient-of-variability of approximately 10% in the voxelwise estimation of the effective MR radius is observed in the test-retest analysis, but it is shown that the performance can be improved fourfold using a customized along-tract analysis.

SUBMITTER: Veraart J 

PROVIDER: S-EPMC8046139 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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The variability of MR axon radii estimates in the human white matter.

Veraart Jelle J   Raven Erika P EP   Edwards Luke J LJ   Weiskopf Nikolaus N   Jones Derek K DK  

Human brain mapping 20210212 7


The noninvasive quantification of axonal morphology is an exciting avenue for gaining understanding of the function and structure of the central nervous system. Accurate non-invasive mapping of micron-sized axon radii using commonly applied neuroimaging techniques, that is, diffusion-weighted MRI, has been bolstered by recent hardware developments, specifically MR gradient design. Here the whole brain characterization of the effective MR axon radius is presented and the inter- and intra-scanner  ...[more]

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