Computerized spermatogenesis staging (CSS) of mouse testis sections via quantitative histomorphological analysis.

ABSTRACT: Spermatogenesis in mammals is a cyclic process of spermatogenic cell development in the seminiferous epithelium that can be subdivided into 12 subsequent stages. Histological staging analysis of testis sections, specifically of seminiferous tubule cross-sections, is the only effective method to evaluate the quality of the spermatogenic process and to determine developmental defects leading to infertility. Such staging analysis, however, is tedious and time-consuming, and it may take a long time to become proficient. We now have developed a Computerized Staging system of Spermatogenesis (CSS) for mouse testis sections through learning of an expert with decades of experience in mouse testis staging. The development of the CSS system comprised three major parts: 1) Developing computational im

SUBMITTER: Xu J 

PROVIDER: S-EPMC8046964 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature