Factors associated with change in frailty scores and long-term outcomes in older adults with coronary artery disease.

ABSTRACT:

Objective

Older adults with coronary artery disease (CAD) are at risk for frailty. However, little is known regarding transition in frailty measures over time or its impact on outcomes. We sought to determine the association of temporal change in frailty with long-term outcome in older adults with CAD.

Methods

We re-assessed for phenotypic frailty using the Fried index (0 = not frail; 1-2 = pre-frail; ≥ 3 frail) in a cohort of CAD patients ≥ 65 years old at 2 time points 5 years apart. Factors associated with frailty worsening were assessed with scatterplots and outcomes estimated using the Kaplan-Meier method. Cox models were used to assess the risk of worsening frailty on outcome.

Results

There were 45 subjects that completed both baseline and 5-year Fried frailty a

SUBMITTER: Gharacholou SM 

PROVIDER: S-EPMC8047182 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature