Plasmodium falciparum finds the winning combination.

ABSTRACT: After 3 years of laboratory drug pressure in the presence of a picomolar inhibitor, the parasite Plasmodium falciparum developed a combination strategy of gene amplification and mutation to regain viability. The mutation observed led to a dysfunctional enzyme, but new research reveals the clever mechanism behind its success. Not that we needed a reminder of nature's creativity in the time of a pandemic.

SUBMITTER: Hengge AC 

PROVIDER: S-EPMC8047455 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature