One Stone, Two Birds: The Roles of Tim-3 in Acute Myeloid Leukemia.
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ABSTRACT: T cell immunoglobulin and mucin protein 3 (Tim-3) is an immune checkpoint and plays a vital role in immune responses during acute myeloid leukemia (AML). Targeting Tim-3 kills two birds with one stone by balancing the immune system and eliminating leukemia stem cells (LSCs) in AML. These functions make Tim-3 a potential target for curing AML. This review mainly discusses the roles of Tim-3 in the immune system in AML and as an AML LSC marker, which sheds new light on the role of Tim-3 in AML immunotherapy.
SUBMITTER: Wang Z
PROVIDER: S-EPMC8047468 | biostudies-literature |
REPOSITORIES: biostudies-literature
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