Carnitine palmitoyl transferase 1A is a novel diagnostic and predictive biomarker for breast cancer.

ABSTRACT:

Background

Carnitine palmitoyl transferase 1A (CPT1A), the key regulator of fatty acid oxidation, contributes to tumor metastasis and therapeutic resistance. We aimed to identify its clinical significance as a biomarker for the diagnosis and prediction of breast cancer.

Methods

Western blot, ELISA and in silico analysis were used to confirm CPT1A levels in breast cancer cell lines, cell culture medium and breast cancer tissues. Four hundred thirty breast cancer patients, 200 patients with benign breast disease, and 400 healthy controls were enrolled and randomly divided into a training set and a test set with a 7:3 ratio. Training set was used to build diagnostic models and 10-fold cross validation was used to demonstrate the performance of the models. Then test set was aime

SUBMITTER: Tan Z 

PROVIDER: S-EPMC8048260 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature