Blood eosinophils associate with reduced lung function growth in adolescent asthmatics.

ABSTRACT:

Background and objective

Some children with asthma have low lung growth, putting them at increased risk for COPD later in life. However, it is currently not clear who will experience this adverse growth pattern. We therefore investigated the predictive role of blood eosinophils as a type 2 inflammation marker in lung growth, focusing on the presence and severity of asthma.

Methods

We investigated blood eosinophils and lung function growth (percentage of predicted values) using linear mixed models in children and adolescents from two longitudinal cohorts. One cohort was hospital-based and consisted of asthmatic children at their first outpatient clinic visit after referral by the general practitioner (n = 133, mean age 9.8), while the second was a general population-based bir

SUBMITTER: Koefoed HJL 

PROVIDER: S-EPMC8048657 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature