Dataset Information

Prognostic impact of sarcopenia in cirrhotic patients stratified by different severity of portal hypertension.

ABSTRACT:

Background and aims

Portal hypertension (PH) and sarcopenia are common in patients with advanced chronic liver disease (ACLD). However, the interaction between PH and sarcopenia and their specific and independent impact on prognosis and mortality has yet to be systematically investigated in patients with ACLD.

Methods

Consecutive patients with ACLD and hepatic venous pressure gradient (HVPG) ≥10 mm Hg with available CT/MRI imaging were included. Sarcopenia was defined by transversal psoas muscle thickness (TPMT) at <12 mm/m in men and <8 mm/m in women at the level of the third lumbar vertebrae. Hepatic decompensation and mortality was recorded during follow-up.

Results

Among 203 patients (68% male, age: 55 ± 11, model for end-stage liver disease [MELD]: 12 [9-15]), sarcopenia was observed in 77 (37.9%) and HVPG was ≥20 mm Hg in 98 (48.3%). There was no correlation between TPMT and HVPG (r = .031, P = .66), median HVPG was not different between patients with vs without sarcopenia (P = .211). Sarcopenia was significantly associated with first/further decompensation both in compensated (SHR: 3.05, P = .041) and in decompensated patients (SHR: 1.86, P = .021). Furthermore, sarcopenia (SARC) was a significant predictor of mortality irrespective of HVPG (HVPG < 20-SARC: SHR: 2.25, P = .021; HVPG ≥ 20-SARC: SHR: 3.33, P = .001). On multivariate analysis adjusted for age, HVPG and MELD, sarcopenia was an independent risk factor for mortality (aHR: 1.99, 95% confidence interval: 1.2-3.3, P = .007).

Conclusion

Sarcopenia has a major impact on clinical outcomes both in compensated and in decompensated ACLD patients. The presence of sarcopenia doubled the risk for mortality independently from the severity of PH.

SUBMITTER: Paternostro R

PROVIDER: S-EPMC8048669 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Publications

Prognostic impact of sarcopenia in cirrhotic patients stratified by different severity of portal hypertension.

Paternostro Rafael R Bardach Constanze C Hofer Benedikt S BS Scheiner Bernhard B Schwabl Philipp P Asenbaum Ulrika U Ba-Ssalamah Ahmed A Scharitzer Martina M Bucscis Theresa T Simbrunner Benedikt B Bauer David D Trauner Michael M Mandorfer Mattias M Reiberger Thomas T Lampichler Katharina K

Liver international : official journal of the International Association for the Study of the Liver 20201222 4

<h4>Background and aims</h4>Portal hypertension (PH) and sarcopenia are common in patients with advanced chronic liver disease (ACLD). However, the interaction between PH and sarcopenia and their specific and independent impact on prognosis and mortality has yet to be systematically investigated in patients with ACLD.<h4>Methods</h4>Consecutive patients with ACLD and hepatic venous pressure gradient (HVPG) ≥10 mm Hg with available CT/MRI imaging were included. Sarcopenia was defined by transvers ...[more]

PMID: 33290614

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Dataset Information

Prognostic impact of sarcopenia in cirrhotic patients stratified by different severity of portal hypertension.

Background and aims

Methods

Results

Conclusion

Publications

Prognostic impact of sarcopenia in cirrhotic patients stratified by different severity of portal hypertension.

Similar Datasets

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