Circulating senescent angiogenic T cells are linked with endothelial dysfunction and systemic inflammation in hypertension.

ABSTRACT:

Objective

Angiogenic T cells (Tang cells), a recently discovered T-cell subset, have been reported involved in the repair of endothelial injury. The purpose of this study was to explore the correlation of immunologic senescence and pro-inflammatory capacity of Tang cells with endothelial dysfunction in hypertensive patients.

Methods

Immunological characteristics of Tang cells (CD3+CD31+CXCR4+) from hypertensive patients with or without endothelial dysfunction were elucidated by surface immunophenotyping and intracellular cytokine staining. Endothelial function was measured by flow-mediated dilation (FMD).

Results

The frequency of CD28null subset in CD4+ Tang cells was notably elevated in hypertensive patients with endothelial dysfunction, which was negatively associat

SUBMITTER: Zhang G 

PROVIDER: S-EPMC8048736 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature