Axon-Myelin Unit Blistering as Early Event in MS Normal Appearing White Matter.

ABSTRACT:

Objective

Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease of unknown etiology. Although the prevalent view regards a CD4⁺ -lymphocyte autoimmune reaction against myelin at the root of the disease, recent studies propose autoimmunity as a secondary reaction to idiopathic brain damage. To gain knowledge about this possibility we investigated the presence of axonal and myelinic morphological alterations, which could implicate imbalance of axon-myelin units as primary event in MS pathogenesis.

Methods

Using high resolution imaging histological brain specimens from patients with MS and non-neurological/non-MS controls, we explored molecular changes underpinning imbalanced interaction between axon and myelin in normal appearing white

SUBMITTER: Luchicchi A 

PROVIDER: S-EPMC8048993 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature