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Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans.

ABSTRACT: We studied mucosal immune responses in six HIV-1 vaccine trials investigating different envelope (Env)-containing immunogens. Regimens were classified into four categories: DNA/vector, DNA/vector plus protein, protein alone, and vector alone. We measured HIV-1-specific IgG and IgA in secretions from cervical (n = 111) and rectal swabs (n = 154), saliva (n = 141), and seminal plasma (n = 124) and compared to corresponding blood levels. Protein-containing regimens had up to 100% response rates and the highest Env-specific IgG response rates. DNA/vector groups elicited mucosal Env-specific IgG response rates of up to 67% that varied across specimen types. Little to no mucosal IgA responses were observed. Overall, gp41- and gp140-specific antibodies dominated gp120 mucosal responses. In one trial, prior vaccination with a protein-containing immunogen maintained durability of cervical and rectal IgG for up to 17 years. Mucosal IgG responses were boosted after revaccination. These findings highlight a role for protein immunization in eliciting HIV-1-specific mucosal antibodies and the ability of HIV-1 vaccines to elicit durable HIV-1-specific mucosal IgG.

SUBMITTER: Seaton KE

PROVIDER: S-EPMC8050318 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans.

Seaton Kelly E KE Deal Aaron A Han Xue X Li Shuying S SS Clayton Ashley A Heptinstall Jack J Duerr Ann A Allen Mary A MA Shen Xiaoying X Sawant Sheetal S Yates Nicole L NL Spearman Paul P Churchyard Gavin G Goepfert Paul A PA Maenza Janine J Gray Glenda G Pantaleo Giuseppe G Polakowski Laura L Robinson Harriet L HL Grant Shannon S Randhawa April K AK Huang Ying Y Morgan Cecilia C Grunenberg Nicole N Karuna Shelly S Gilbert Peter B PB McElrath M Juliana MJ Huang Yunda Y Tomaras Georgia D GD

NPJ vaccines 20210415 1

We studied mucosal immune responses in six HIV-1 vaccine trials investigating different envelope (Env)-containing immunogens. Regimens were classified into four categories: DNA/vector, DNA/vector plus protein, protein alone, and vector alone. We measured HIV-1-specific IgG and IgA in secretions from cervical (n = 111) and rectal swabs (n = 154), saliva (n = 141), and seminal plasma (n = 124) and compared to corresponding blood levels. Protein-containing regimens had up to 100% response rates and ...[more]

PMID: 33859204

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Dataset Information

Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans.

Publications

Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans.

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