Ontology highlight
ABSTRACT:
SUBMITTER: Wei Y
PROVIDER: S-EPMC8053081 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Wei Yue Y Huang Qinqin Q Tian Xihao X Zhang Mingmin M He Junkai J Chen Xingxiang X Chen Chao C Deng Zixin Z Li Zhiqiang Z Chen Shi S Wang Lianrong L
Nucleic acids research 20210401 7
DNA phosphorothioate (PT) modifications, with the nonbridging phosphate oxygen replaced by sulfur, governed by DndABCDE or SspABCD, are widely distributed in prokaryotes and have a highly unusual feature of occupying only a small portion of available consensus sequences in a genome. Despite the presence of plentiful non-PT-protected consensuses, DNA PT modification is still employed as a recognition tag by the restriction cognate, for example, DndFGH or SspE, to discriminate and destroy PT-lacki ...[more]