Dataset Information

Prostate Stereotactic Body Radiation Therapy: An Overview of Toxicity and Dose Response.

ABSTRACT:

Purpose

Ultrahypofractionationed radiation therapy for prostate cancer is increasingly studied and adopted. The American Association of Physicists in Medicine Working Group on Biological Effects of Hypofractionated Radiotherapy therefore aimed to review studies examining toxicity and quality of life after stereotactic body radiation therapy (SBRT) for prostate cancer and model its effect.

Methods and materials

We performed a systematic PubMed search of prostate SBRT studies published between 2001 and 2018. Those that analyzed factors associated with late urinary, bowel, or sexual toxicity and/or quality of life were included and reviewed. Normal tissue complication probability modelling was performed on studies that contained detailed dose/volume and outcome data.

Results

We found 13 studies that examined urinary effects, 6 that examined bowel effects, and 4 that examined sexual effects. Most studies included patients with low-intermediate risk prostate cancer treated to 35-40 Gy. Most patients were treated with 5 fractions, with several centers using 4 fractions. Endpoints were heterogeneous and included both physician-scored toxicity and patient-reported quality of life. Most toxicities were mild-moderate (eg, grade 1-2) with a very low overall incidence of severe toxicity (eg, grade 3 or higher, usually <3%). Side effects were associated with both dosimetric and non-dosimetric factors.

Conclusions

Prostate SBRT appears to be overall well tolerated, with determinants of toxicity that include dosimetric factors and patient factors. Suggested dose constraints include bladder V(Rx Dose)Gy <5-10 cc, urethra Dmax <38-42 Gy, and rectum Dmax <35-38 Gy, though current data do not offer firm guidance on tolerance doses. Several areas for future research are suggested.

SUBMITTER: Wang K

PROVIDER: S-EPMC8053668 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Publications

Prostate Stereotactic Body Radiation Therapy: An Overview of Toxicity and Dose Response.

Wang Kyle K Mavroidis Panayiotis P Royce Trevor J TJ Falchook Aaron D AD Collins Sean P SP Sapareto Stephen S Sheets Nathan C NC Fuller Donald B DB El Naqa Issam I Yorke Ellen E Grimm Jimm J Jackson Andrew A Chen Ronald C RC

International journal of radiation oncology, biology, physics 20201222 1

<h4>Purpose</h4>Ultrahypofractionationed radiation therapy for prostate cancer is increasingly studied and adopted. The American Association of Physicists in Medicine Working Group on Biological Effects of Hypofractionated Radiotherapy therefore aimed to review studies examining toxicity and quality of life after stereotactic body radiation therapy (SBRT) for prostate cancer and model its effect.<h4>Methods and materials</h4>We performed a systematic PubMed search of prostate SBRT studies publis ...[more]

PMID: 33358229

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Dataset Information

Prostate Stereotactic Body Radiation Therapy: An Overview of Toxicity and Dose Response.

Purpose

Methods and materials

Results

Conclusions

Publications

Prostate Stereotactic Body Radiation Therapy: An Overview of Toxicity and Dose Response.

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