Annotation and initial evaluation of a large annotated German oncological corpus.
Ontology highlight
ABSTRACT: Objective
We present the Berlin-Tübingen-Oncology corpus (BRONCO), a large and freely available corpus of shuffled sentences from German oncological discharge summaries annotated with diagnosis, treatments, medications, and further attributes including negation and speculation. The aim of BRONCO is to foster reproducible and openly available research on Information Extraction from German medical texts.Materials and methods
BRONCO consists of 200 manually deidentified discharge summaries of cancer patients. Annotation followed a structured and quality-controlled process involving 2 groups of medical experts to ensure consistency, comprehensiveness, and high quality of annotations. We present results of several state-of-the-art techniques for different IE tasks as baselines for subsequent research.Results
The annotated corpus consists of 11 434 sentences and 89 942 tokens, annotated with 11 124 annotations for medical entities and 3118 annotations of related attributes. We publish 75% of the corpus as a set of shuffled sentences, and keep 25% as held-out data set for unbiased evaluation of future IE tools. On this held-out dataset, our baselines reach depending on the specific entity types F1-scores of 0.72-0.90 for named entity recognition, 0.10-0.68 for entity normalization, 0.55 for negation detection, and 0.33 for speculation detection.Discussion
Medical corpus annotation is a complex and time-consuming task. This makes sharing of such resources even more important.Conclusion
To our knowledge, BRONCO is the first sizable and freely available German medical corpus. Our baseline results show that more research efforts are necessary to lift the quality of information extraction in German medical texts to the level already possible for English.
SUBMITTER: Kittner M
PROVIDER: S-EPMC8054032 | biostudies-literature |
REPOSITORIES: biostudies-literature
Similar Datasets
Project description:We present Chia, a novel, large annotated corpus of patient eligibility criteria extracted from 1,000 interventional, Phase IV clinical trials registered in ClinicalTrials.gov. This dataset includes 12,409 annotated eligibility criteria, represented by 41,487 distinctive entities of 15 entity types and 25,017 relationships of 12 relationship types. Each criterion is represented as a directed acyclic graph, which can be easily transformed into Boolean logic to form a database query. Chia can serve as a shared benchmark to develop and test future machine learning, rule-based, or hybrid methods for information extraction from free-text clinical trial eligibility criteria.
| S-EPMC7452886 | biostudies-literature
Project description:Cyberbullying (CB) is classified as one of the severe misconducts on social media. Many CB detection systems have been developed for many natural languages to face this phenomenon. However, Arabic is one of the under-resourced languages suffering from the lack of quality datasets in many computational research areas. This paper discusses the design, construction, and evaluation of a multi-dialect, annotated Arabic Cyberbullying Corpus (ArCybC), a valuable resource for Arabic CB detection and motivation for future research directions in Arabic Natural Language Processing (NLP). The study describes the phases of ArCybC compilation. By way of illustration, it explores the corpus to discover strategies used in rendering Arabic CB tweets pulled from four Twitter groups, including gaming, sports, news, and celebrities. Based on thorough analysis, we discovered that these groups were the most susceptible to harassment and cyberbullying. The collected tweets were filtered based on a compiled harassment lexicon, which contains a list of multi-dialectical profane words in Arabic compiled from four categories: sexual, racial, physical appearance, and intelligence. To annotate ArCybC, we asked five annotators to classify 4,505 tweets into two classes manually: Offensive/non-Offensive and CB/non-CB. We conducted a rigorous comparison of different machine learning approaches applied on ArCybC to detect Arabic CB using two language models: bag-of-words (BoW) and word embedding. The experiments showed that Support Vector Machine (SVM) with word embedding achieved an accuracy rate of 86.3% and an F1-score rate of 85%. The main challenges encountered during the ArCybC construction were the scarcity of freely available Arabic CB texts and the deficiency of annotating the texts.
| S-EPMC9046013 | biostudies-literature
Project description:Coreference resolution is the task of finding strings in text that have the same referent as other strings. Failures of coreference resolution are a common cause of false negatives in information extraction from the scientific literature. In order to better understand the nature of the phenomenon of coreference in biomedical publications and to increase performance on the task, we annotated the Colorado Richly Annotated Full Text (CRAFT) corpus with coreference relations.The corpus was manually annotated with coreference relations, including identity and appositives for all coreferring base noun phrases. The OntoNotes annotation guidelines, with minor adaptations, were used. Interannotator agreement ranges from 0.480 (entity-based CEAF) to 0.858 (Class-B3), depending on the metric that is used to assess it. The resulting corpus adds nearly 30,000 annotations to the previous release of the CRAFT corpus. Differences from related projects include a much broader definition of markables, connection to extensive annotation of several domain-relevant semantic classes, and connection to complete syntactic annotation. Tool performance was benchmarked on the data. A publicly available out-of-the-box, general-domain coreference resolution system achieved an F-measure of 0.14 (B3), while a simple domain-adapted rule-based system achieved an F-measure of 0.42. An ensemble of the two reached F of 0.46. Following the IDENTITY chains in the data would add 106,263 additional named entities in the full 97-paper corpus, for an increase of 76% percent in the semantic classes of the eight ontologies that have been annotated in earlier versions of the CRAFT corpus.The project produced a large data set for further investigation of coreference and coreference resolution in the scientific literature. The work raised issues in the phenomenon of reference in this domain and genre, and the paper proposes that many mentions that would be considered generic in the general domain are not generic in the biomedical domain due to their referents to specific classes in domain-specific ontologies. The comparison of the performance of a publicly available and well-understood coreference resolution system with a domain-adapted system produced results that are consistent with the notion that the requirements for successful coreference resolution in this genre are quite different from those of the general domain, and also suggest that the baseline performance difference is quite large.
| S-EPMC5561560 | biostudies-other
Project description:Pharmacogenomics (PGx) studies how individual gene variations impact drug response phenotypes, which makes PGx-related knowledge a key component towards precision medicine. A significant part of the state-of-the-art knowledge in PGx is accumulated in scientific publications, where it is hardly reusable by humans or software. Natural language processing techniques have been developed to guide experts who curate this amount of knowledge. But existing works are limited by the absence of a high quality annotated corpus focusing on PGx domain. In particular, this absence restricts the use of supervised machine learning. This article introduces PGxCorpus, a manually annotated corpus, designed to fill this gap and to enable the automatic extraction of PGx relationships from text. It comprises 945 sentences from 911 PubMed abstracts, annotated with PGx entities of interest (mainly gene variations, genes, drugs and phenotypes), and relationships between those. In this article, we present the corpus itself, its construction and a baseline experiment that illustrates how it may be leveraged to synthesize and summarize PGx knowledge.
| S-EPMC6940385 | biostudies-literature
Project description:The existence of annotated text corpora is essential for the development of public health services and tools based on natural language processing (NLP) and text mining. Recently organized biomedical NLP shared tasks have provided annotated corpora related to different biomedical entities such as genes, phenotypes, drugs, diseases and chemical entities. These are needed to develop named-entity recognition (NER) models that are used for extracting entities from text and finding their relations. However, to the best of our knowledge, there are limited annotated corpora that provide information about food entities despite food and dietary management being an essential public health issue. Hence, we developed a new annotated corpus of food entities, named FoodBase. It was constructed using recipes extracted from Allrecipes, which is currently the largest food-focused social network. The recipes were selected from five categories: 'Appetizers and Snacks', 'Breakfast and Lunch', 'Dessert', 'Dinner' and 'Drinks'. Semantic tags used for annotating food entities were selected from the Hansard corpus. To extract and annotate food entities, we applied a rule-based food NER method called FoodIE. Since FoodIE provides a weakly annotated corpus, by manually evaluating the obtained results on 1000 recipes, we created a gold standard of FoodBase. It consists of 12?844 food entity annotations describing 2105 unique food entities. Additionally, we provided a weakly annotated corpus on an additional 21?790 recipes. It consists of 274?053 food entity annotations, 13?079 of which are unique. The FoodBase corpus is necessary for developing corpus-based NER models for food science, as a new benchmark dataset for machine learning tasks such as multi-class classification, multi-label classification and hierarchical multi-label classification. FoodBase can be used for detecting semantic differences/similarities between food concepts, and after all we believe that it will open a new path for learning food embedding space that can be used in predictive studies.
| S-EPMC6827550 | biostudies-literature
Project description:BackgroundHealth question-answering (QA) systems have become a typical application scenario of Artificial Intelligent (AI). An annotated question corpus is prerequisite for training machines to understand health information needs of users. Thus, we aimed to develop an annotated classification corpus of Chinese health questions (Qcorp) and make it openly accessible.MethodsWe developed a two-layered classification schema and corresponding annotation rules on basis of our previous work. Using the schema, we annotated 5000 questions that were randomly selected from 5 Chinese health websites within 6 broad sections. 8 annotators participated in the annotation task, and the inter-annotator agreement was evaluated to ensure the corpus quality. Furthermore, the distribution and relationship of the annotated tags were measured by descriptive statistics and social network map.ResultsThe questions were annotated using 7101 tags that covers 29 topic categories in the two-layered schema. In our released corpus, the distribution of questions on the top-layered categories was treatment of 64.22%, diagnosis of 37.14%, epidemiology of 14.96%, healthy lifestyle of 10.38%, and health provider choice of 4.54% respectively. Both the annotated health questions and annotation schema were openly accessible on the Qcorp website. Users can download the annotated Chinese questions in CSV, XML, and HTML format.ConclusionsWe developed a Chinese health question corpus including 5000 manually annotated questions. It is openly accessible and would contribute to the intelligent health QA system development.
| S-EPMC5872377 | biostudies-literature
Project description:Manually annotated corpora are critical for the training and evaluation of automated methods to identify concepts in biomedical text.This paper presents the concept annotations of the Colorado Richly Annotated Full-Text (CRAFT) Corpus, a collection of 97 full-length, open-access biomedical journal articles that have been annotated both semantically and syntactically to serve as a research resource for the biomedical natural-language-processing (NLP) community. CRAFT identifies all mentions of nearly all concepts from nine prominent biomedical ontologies and terminologies: the Cell Type Ontology, the Chemical Entities of Biological Interest ontology, the NCBI Taxonomy, the Protein Ontology, the Sequence Ontology, the entries of the Entrez Gene database, and the three subontologies of the Gene Ontology. The first public release includes the annotations for 67 of the 97 articles, reserving two sets of 15 articles for future text-mining competitions (after which these too will be released). Concept annotations were created based on a single set of guidelines, which has enabled us to achieve consistently high interannotator agreement.As the initial 67-article release contains more than 560,000 tokens (and the full set more than 790,000 tokens), our corpus is among the largest gold-standard annotated biomedical corpora. Unlike most others, the journal articles that comprise the corpus are drawn from diverse biomedical disciplines and are marked up in their entirety. Additionally, with a concept-annotation count of nearly 100,000 in the 67-article subset (and more than 140,000 in the full collection), the scale of conceptual markup is also among the largest of comparable corpora. The concept annotations of the CRAFT Corpus have the potential to significantly advance biomedical text mining by providing a high-quality gold standard for NLP systems. The corpus, annotation guidelines, and other associated resources are freely available at http://bionlp-corpora.sourceforge.net/CRAFT/index.shtml.
| S-EPMC3476437 | biostudies-literature
Project description:BackgroundInformation Extraction (IE) is a component of text mining that facilitates knowledge discovery by automatically locating instances of interesting biomedical events from huge document collections. As events are usually centred on verbs and nominalised verbs, understanding the syntactic and semantic behaviour of these words is highly important. Corpora annotated with information concerning this behaviour can constitute a valuable resource in the training of IE components and resources.ResultsWe have defined a new scheme for annotating sentence-bound gene regulation events, centred on both verbs and nominalised verbs. For each event instance, all participants (arguments) in the same sentence are identified and assigned a semantic role from a rich set of 13 roles tailored to biomedical research articles, together with a biological concept type linked to the Gene Regulation Ontology. To our knowledge, our scheme is unique within the biomedical field in terms of the range of event arguments identified. Using the scheme, we have created the Gene Regulation Event Corpus (GREC), consisting of 240 MEDLINE abstracts, in which events relating to gene regulation and expression have been annotated by biologists. A novel method of evaluating various different facets of the annotation task showed that average inter-annotator agreement rates fall within the range of 66% - 90%.ConclusionThe GREC is a unique resource within the biomedical field, in that it annotates not only core relationships between entities, but also a range of other important details about these relationships, e.g., location, temporal, manner and environmental conditions. As such, it is specifically designed to support bio-specific tool and resource development. It has already been used to acquire semantic frames for inclusion within the BioLexicon (a lexical, terminological resource to aid biomedical text mining). Initial experiments have also shown that the corpus may viably be used to train IE components, such as semantic role labellers. The corpus and annotation guidelines are freely available for academic purposes.
| S-EPMC2774701 | biostudies-literature
Project description:Clinical case reports are the `eyewitness reports' of medicine and provide a valuable, unique, albeit noisy and underutilized type of evidence. Generally a case report has a single main finding that represents the reason for writing up the report in the first place. In the present study, we present the results of manual annotation carried out by two individuals on 500 randomly sampled case reports. This corpus contains main finding sentences extracted from title, abstract and full-text of the same article that can be regarded as semantically related and are often paraphrases. The final reconciled corpus of 416 articles comprises an open resource for further study. This is the first step in establishing text mining models and tools that can identify main finding sentences in an automated fashion, and in measuring quantitatively how similar any two main findings are. We envision that case reports in PubMed may be automatically indexed by main finding, so that users can carry out information queries for specific main findings (rather than general topics)-and given one case report, a user can retrieve those having the most similar main findings. The metric of main finding similarity may also potentially be relevant to the modeling of paraphrasing, summarization and entailment within the biomedical literature.
| S-EPMC6335863 | biostudies-other
Project description:BackgroundDetecting uncertain and negative assertions is essential in most BioMedical Text Mining tasks where, in general, the aim is to derive factual knowledge from textual data. This article reports on a corpus annotation project that has produced a freely available resource for research on handling negation and uncertainty in biomedical texts (we call this corpus the BioScope corpus).ResultsThe corpus consists of three parts, namely medical free texts, biological full papers and biological scientific abstracts. The dataset contains annotations at the token level for negative and speculative keywords and at the sentence level for their linguistic scope. The annotation process was carried out by two independent linguist annotators and a chief linguist--also responsible for setting up the annotation guidelines --who resolved cases where the annotators disagreed. The resulting corpus consists of more than 20.000 sentences that were considered for annotation and over 10% of them actually contain one (or more) linguistic annotation suggesting negation or uncertainty.ConclusionStatistics are reported on corpus size, ambiguity levels and the consistency of annotations. The corpus is accessible for academic purposes and is free of charge. Apart from the intended goal of serving as a common resource for the training, testing and comparing of biomedical Natural Language Processing systems, the corpus is also a good resource for the linguistic analysis of scientific and clinical texts.
| S-EPMC2586758 | biostudies-literature