Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC8054725 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Chen Lin L Wei Zhiliang Z Chan Kannie Wy KW Li Yuguo Y Suchal Kapil K Bi Sheng S Huang Jianpan J Xu Xiang X Wong Philip C PC Lu Hanzhang H van Zijl Peter Cm PC Li Tong T Xu Jiadi J
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20200716 5
In this study, we applied on-resonance variable delay multiple pulse (onVDMP) MRI to study D-glucose uptake in a mouse model of Alzheimer's disease (AD) tauopathy and demonstrated its feasibility in discriminating AD mice from wild-type mice. The D-glucose uptake in the cortex of AD mice (1.70 ± 1.33%) was significantly reduced compared to that of wild-type mice (5.42 ± 0.70%, <i>p</i> = 0.0051). Also, a slower D-glucose uptake rate was found in the cerebrospinal fluid (CSF) of AD mice (0.08 ± 0 ...[more]