Reduction in circulating vitamin D binding protein in patients with multiple sclerosis.

ABSTRACT:

Background

In this study, we aimed to determine the risk association between vitamin D binding protein (VDBP) polymorphism in patients with multiple sclerosis (MS) in a MS biobank and the difference in VDBP serum levels in MS patients who were recently diagnosed.

Method

The current case-control study was performed on 296 MS patients and 313 controls. Thereafter, two common missense VDBP polymorphisms, named rs7041and rs4588, were evaluated in all the participants. Serum levels of vitamin D and vitamin D binding protein were assessed in 77 MS patients who were diagnosed since one year ago and in 67 healthy people who were matched in terms of age and sex.

Result

The frequency distributions of VDBP genotypes and alleles of SNP rs7041 and rs4588 were observed to be simila

SUBMITTER: Maghbooli Z 

PROVIDER: S-EPMC8056586 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature