Ontology highlight
ABSTRACT:
SUBMITTER: Zhao S
PROVIDER: S-EPMC8057083 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Channels (Austin, Tex.) 20211201 1
Transient Receptor Potential Melastatin 3 (TRPM3) is a Ca<sup>2+</sup> permeable nonselective cation channel, activated by heat and chemical agonists, such as the endogenous neuro-steroid Pregnenolone Sulfate (PregS) and the chemical compound CIM0216. TRPM3 is expressed in peripheral sensory neurons of the dorsal root ganglia (DRG), and its role in noxious heat sensation in mice is well established. TRPM3 is also expressed in a number of other tissues, including the brain, but its role there has ...[more]