Association between surgery with anesthesia and cognitive decline in older adults: Analysis using shared parameter models for informative dropout.

ABSTRACT:

Objectives/goals

The association between surgery with general anesthesia (exposure) and cognition (outcome) among older adults has been studied with mixed conclusions. We revisited a recent analysis to provide missing data education and discuss implications of biostatistical methodology for informative dropout following dementia diagnosis.

Methods/study population

We used data from the Mayo Clinic Study of Aging, a longitudinal study of prevalence, incidence, and risk factors for mild cognitive impairment (MCI) and dementia. We fit linear mixed effects models (LMMs) to assess the association between anesthesia exposure and subsequent trajectories of cognitive z-scores assuming data missing at random, hypothesizing that exposure is associated with greater decline in co

SUBMITTER: Devick KL 

PROVIDER: S-EPMC8057447 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature