Dataset Information
Biomarkers and indoor air quality: A translational research review.
Ontology highlight
ABSTRACT: Introduction
Air pollution is linked to mortality and morbidity. Since humans spend nearly all their time indoors, improving indoor air quality (IAQ) is a compelling approach to mitigate air pollutant exposure. To assess interventions, relying on clinical outcomes may require prolonged follow-up, which hinders feasibility. Thus, identifying biomarkers that respond to changes in IAQ may be useful to assess the effectiveness of interventions.Methods
We conducted a narrative review by searching several databases to identify studies published over the last decade that measured the response of blood, urine, and/or salivary biomarkers to variations (natural and intervention-induced) of changes in indoor air pollutant exposure.Results
Numerous studies reported on associations between IAQ exposures and biomarkers with heterogeneity across study designs and methods. This review summarizes the responses of 113 biomarkers described in 30 articles. The biomarkers which most frequently responded to variations in indoor air pollutant exposures were high sensitivity C-reactive protein (hsCRP), von Willebrand Factor (vWF), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and 1-hydroxypyrene (1-OHP).Conclusions
This review will guide the selection of biomarkers for translational studies evaluating the impact of indoor air pollutants on human health.
SUBMITTER: Senerat AM
PROVIDER: S-EPMC8057458 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Biomarkers and indoor air quality: A translational research review.
Journal of clinical and translational science 20200904 1
<h4>Introduction</h4>Air pollution is linked to mortality and morbidity. Since humans spend nearly all their time indoors, improving indoor air quality (IAQ) is a compelling approach to mitigate air pollutant exposure. To assess interventions, relying on clinical outcomes may require prolonged follow-up, which hinders feasibility. Thus, identifying biomarkers that respond to changes in IAQ may be useful to assess the effectiveness of interventions.<h4>Methods</h4>We conducted a narrative review ...[more]