The UPTAKE study: implications for the future of COVID-19 vaccination trial recruitment in UK and beyond.

ABSTRACT:

Background

Developing a safe and effective vaccine will be the principal way of controlling the COVID-19 pandemic. However, current COVID-19 vaccination trials are not adequately representing a diverse participant population in terms of age, ethnicity and comorbidities. Achieving the representative recruitment targets that are adequately powered to the study remains one of the greatest challenges in clinical trial management. To ensure accuracy and generalisability of the safety and efficacy conclusions generated by clinical trials, it is crucial to recruit patient cohorts as representative as possible of the future target population. Missing these targets can lead to reduced validity of the study results and can often slow down drug development leading to costly delays.

Objecti

SUBMITTER: Sethi S 

PROVIDER: S-EPMC8057665 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature