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Analysis of 12 GWAS-Linked Loci With Parkinson's Disease in the Chinese Han Population.

ABSTRACT: A recent large-scale European-originated genome-wide association study identified 38 novel independent risk signals in 37 loci for Parkinson's disease (PD). However, whether these new loci are associated with PD in Asian populations remains elusive. The present study aimed to explore the relationship between the 12 most relevant loci with larger absolute values for these new risk loci and PD in the Chinese Han population. We performed a case-control study including 527 PD patients and 435 healthy controls. In the allele model, it was found that rs10748818/GBF1 was associated with PD in the Chinese Han population [p = 0.035, odds ratio (OR) 1.221, 95% confidence interval (CI) 1.014-1.472.

SUBMITTER: Fan L

PROVIDER: S-EPMC8058430 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Analysis of 12 GWAS-Linked Loci With Parkinson's Disease in the Chinese Han Population.

Fan Liyuan L Shi Changhe C Hu Xinchao X Zhang Zhongxian Z Zheng Huimin H Luo Haiyang H Fan Yu Y Zhang Shuo S Hu Zhengwei Z Yang Jing J Mao Chengyuan C Xu Yuming Y

Frontiers in neurology 20210407

A recent large-scale European-originated genome-wide association study identified 38 novel independent risk signals in 37 loci for Parkinson's disease (PD). However, whether these new loci are associated with PD in Asian populations remains elusive. The present study aimed to explore the relationship between the 12 most relevant loci with larger absolute values for these new risk loci and PD in the Chinese Han population. We performed a case-control study including 527 PD patients and 435 health ...[more]

PMID: 33897588

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