Browse
Submit Data
Databases
API
Help

Dataset Information

14 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Analysis of 12 GWAS-Linked Loci With Parkinson's Disease in the Chinese Han Population.

ABSTRACT: A recent large-scale European-originated genome-wide association study identified 38 novel independent risk signals in 37 loci for Parkinson's disease (PD). However, whether these new loci are associated with PD in Asian populations remains elusive. The present study aimed to explore the relationship between the 12 most relevant loci with larger absolute values for these new risk loci and PD in the Chinese Han population. We performed a case-control study including 527 PD patients and 435 healthy controls. In the allele model, it was found that rs10748818/GBF1 was associated with PD in the Chinese Han population [p = 0.035, odds ratio (OR) 1.221, 95% confidence interval (CI) 1.014-1.472.

SUBMITTER: Fan L

PROVIDER: S-EPMC8058430 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Validation of Susceptibility Loci for Vitiligo Identified by GWAS in the Chinese Han Population.

Project description: Not available

| S-EPMC7744663 | biostudies-literature

Replication of Gout/Urate Concentrations GWAS Susceptibility Loci Associated with Gout in a Han Chinese Population.

Project description: Not available

| S-EPMC5481433 | biostudies-literature

Sporadic Parkinson's Disease Potential Risk Loci Identified in Han Ancestry of Chinese Mainland.

Project description: Not available

| S-EPMC7835639 | biostudies-literature

Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese.

Project description: Not available

| S-EPMC4685393 | biostudies-other

Mapping of hepatic expression quantitative trait loci (eQTLs) in a Han Chinese population [SNP analysis]

2015-01-02 | GSE53790 | GEO

Mapping of Hepatic Expression Quantitative Trait Loci (eQTLs) in a Han Chinese Population [Expression analysis]

2015-01-02 | GSE53791 | GEO

Association analysis of GWAS and candidate gene loci in a Chinese population with coronary heart disease.

Project description: Not available

| S-EPMC4509238 | biostudies-literature

Mapping of Hepatic Expression Quantitative Trait Loci (eQTLs) in a Han Chinese Population [Expression analysis]

Project description:Elucidating the genetic basis underlying the variation in hepatic gene expression is of importance to understand disease etiology and drug metabolism variances. To date, no genome-wide eQTL analysis has been conducted in the Han Chinese, the largest ethnic group in the world. We performed a genome-wide eQTL mapping in a set of Han Chinese liver tissue (n=64). Normal (non-diseased) liver tissues were previously collected from 64 Chinese donors who provided informed consent. All samples were stored frozen at -80M-bM-^DM-^C from collection until processing for RNA and DNA extraction. DNA /Total RNA of the human liver tissue samples were extracted by using the RNA/DNA Mini Kit (Qiagen, Hilden, Germany).each RNA sample were labeled and hybridized to the One-Color Agilent 60-mer Whole Human Genome Microarray (G4112F, GPL4133) at the Agilent Microarray Facility of Shanghai genomePilot Technology, Inc. The genome-wide scan was performed using the Affymetrix Genome-Wide Human SNP Array 6.0. We tested all expression traits for their associations with each of the QC passed SNPs using PLINK's assoc function for quantitative traits, which correlates allele dosage with changes in the trait.

2015-01-02 | E-GEOD-53791 | biostudies-arrayexpress

Mapping of Hepatic Expression Quantitative Trait Loci (eQTLs) in a Han Chinese Population [SNP analysis]

Project description:Elucidating the genetic basis underlying the variation in hepatic gene expression is of importance to understand disease etiology and drug metabolism variances. To date, no genome-wide eQTL analysis has been conducted in the Han Chinese, the largest ethnic group in the world. We performed a genome-wide eQTL mapping in a set of Han Chinese liver tissue (n=64). Normal (non-diseased) liver tissues were previously collected from 64 Chinese donors who provided informed consent. All samples were stored frozen at -80℃ from collection until processing for RNA and DNA extraction. DNA /Total RNA of the human liver tissue samples were extracted by using the RNA/DNA Mini Kit (Qiagen, Hilden, Germany).each RNA sample were labeled and hybridized to the One-Color Agilent 60-mer Whole Human Genome Microarray (G4112F, GPL4133) at the Agilent Microarray Facility of Shanghai genomePilot Technology, Inc. The genome-wide scan was performed using the Affymetrix Genome-Wide Human SNP Array 6.0. We tested all expression traits for their associations with each of the QC passed SNPs using PLINK's assoc function for quantitative traits, which correlates allele dosage with changes in the trait.

2015-01-02 | E-GEOD-53790 | biostudies-arrayexpress

Mapping of Hepatic Expression Quantitative Trait Loci (eQTLs) in a Han Chinese Population

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-01-02 | GSE53792 | GEO