FABP5 as a novel molecular target in prostate cancer.
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ABSTRACT:
SUBMITTER: O'Sullivan SE
PROVIDER: S-EPMC8059105 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
FABP5 as a novel molecular target in prostate cancer.
O'Sullivan Saoirse Elizabeth SE Kaczocha Martin M
Drug discovery today 20200920
Emerging evidence suggests that dysregulated lipid signaling is a key factor in prostate cancer (PC), through fatty acid activation of the nuclear receptors peroxisome proliferator-activated receptors (PPARs), leading to the upregulation of protumoral genes. Fatty acid-binding proteins (FABPs) are intracellular lipid-binding proteins that transport fatty acid to PPARs, facilitating their activation. FABP5 is overexpressed in PC, and correlates with poor patient prognosis and survival. Genetic kn ...[more]
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