Dataset Information

Performance of Mattis dementia rating scale-Chinese version in patients with mild cognitive impairment and Alzheimer's disease.

ABSTRACT:

Background

To identify the applicability of the Chinese Version of Mattis Dementia Rating Scale (DRS-CV).

Methods

The DRS-CV was administered to 483 participants, including 136 normal controls, 167 patients with mild cognition impairment (MCI), and 180 patients with Alzheimer's disease (AD). Receiver Operating Characteristic (ROC) curve was used to evaluate the sensitivity and specificity of the scale.

Results

The scores of DRS-CV were ranked in the order of NC > MCI > mild AD > moderate AD group. Memory was the sensitive function affected at a relatively earlier stage of AD. ROC curve analysis indicated the DRS-CV total score and memory subscale showed excellent sensitivity and specificity in the discrimination between MCI from mild AD and mild AD from moderate AD, but poor sensitivity and specificity in the discrimination between MCI and NC.

Conclusion

The DRS-CV is useful to the early diagnosis and severity of AD, not to the early identification of MCI.

SUBMITTER: Qian S

PROVIDER: S-EPMC8059185 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Publications

Performance of Mattis dementia rating scale-Chinese version in patients with mild cognitive impairment and Alzheimer's disease.

Qian Shuxia S Chen Keliang K Guan Qiaobing Q Guo Qihao Q

BMC neurology 20210421 1

<h4>Background</h4>To identify the applicability of the Chinese Version of Mattis Dementia Rating Scale (DRS-CV).<h4>Methods</h4>The DRS-CV was administered to 483 participants, including 136 normal controls, 167 patients with mild cognition impairment (MCI), and 180 patients with Alzheimer's disease (AD). Receiver Operating Characteristic (ROC) curve was used to evaluate the sensitivity and specificity of the scale.<h4>Results</h4>The scores of DRS-CV were ranked in the order of NC > MCI > mild ...[more]

PMID: 33882848

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Project description:OBJECTIVES:While various short variants of the Montreal Cognitive Assessment (MoCA) have been developed, they have not been compared among each other to determine the most optimal variant for routine use. This study evaluated the comparative performance of the short variants in identifying mild cognitive impairment or dementia (MCI/dementia). DESIGN:Baseline data of a cohort study. SETTING:Alzheimer's Disease Centers across the United States. PARTICIPANTS:Participants aged ≥50 years (n = 4606), with median age 70 (interquartile range 65-76). MEASURES:Participants completed MoCA and were evaluated for MCI/dementia. The various short variants of MoCA were compared in their performance in discriminating MCI/dementia, using areas under the receiver operating characteristic curve (AUCs). RESULTS:All 7 short variants of MoCA had acceptable performance in discriminating MCI/dementia from normal cognition (AUC 87.7%-91.0%). However, only 2 variants by Roalf et al (2016) and Wong et al (2015) demonstrated comparable performance (AUC 88.4-88.9%) to the original MoCA (AUC 89.3%). Among the participants with higher education, only the variant by Roalf et al had similar AUC to the original MoCA. At the optimal cut-off score of <25, the original MoCA demonstrated 84.4% sensitivity and 76.4% specificity. In contrast, the short variant by Roalf et al had 87.2% sensitivity and 72.1% specificity at its optimal cut-off score of <13. CONCLUSIONS/IMPLICATIONS:The various short variants may not share similar diagnostic performance, with many limited by ceiling effects among participants with higher education. Only the short variant by Roalf et al was comparable to the original MoCA in identifying MCI or dementia even across education subgroups. This variant is one-third the length of the original MoCA and can be completed in <5 minutes. It provides a viable alternative when it is not feasible to administer the original MoCA in clinical practice and can be especially useful in nonspecialty clinics with large volumes of patients at high risk of cognitive impairment (such as those in primary care, geriatric, and stroke prevention clinics).

Dataset Information

Performance of Mattis dementia rating scale-Chinese version in patients with mild cognitive impairment and Alzheimer's disease.

Background

Methods

Results

Conclusion

Publications

Performance of Mattis dementia rating scale-Chinese version in patients with mild cognitive impairment and Alzheimer's disease.

Similar Datasets

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