MYD88 Is a Potential Prognostic Gene and Immune Signature of Tumor Microenvironment for Gliomas.

ABSTRACT:

Purpose

To explore the profiles of immune and stromal components of the tumor microenvironment (TME) and their related key genes in gliomas.

Methods

We applied bioinformatic techniques to identify the core gene that participated in the regulation of the TME of the gliomas. And immunohistochemistry staining was used to calculate the gene expressions in clinical cases.

Results

The CIBERSORT and ESTIMATE were used to figure out the composition of TME in 698 glioma cases from The Cancer Genome Atlas (TCGA) database. Differential expression analysis identified 2103 genes between the high and the low-score group. Then the Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, univariate Cox regression analysis, and protein-protein interactio

SUBMITTER: Guo Q 

PROVIDER: S-EPMC8059377 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature