Ontology highlight
ABSTRACT:
SUBMITTER: Hushpulian DM
PROVIDER: S-EPMC8060438 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Hushpulian Dmitry M DM Ammal Kaidery Navneet N Ahuja Manuj M Poloznikov Andrey A AA Sharma Sudarshana M SM Gazaryan Irina G IG Thomas Bobby B
Frontiers in aging neuroscience 20210408
The Keap1-Nrf2 signaling axis is a validated and promising target for cellular defense and survival pathways. This minireview discusses the potential off-target effects and their impact on future drug development originating from Keap1-targeting small molecules that function as displacement activators of the redox-sensitive transcription factor Nrf2. We argue that small-molecule displacement activators, similarly to electrophiles, will release both Nrf2 and other Keap1 client proteins from the u ...[more]