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Advances in Cancer Treatment by Targeting the Neddylation Pathway.

ABSTRACT: Developmental down-regulation protein 8 (NEDD8), expressed by neural progenitors, is a ubiquitin-like protein that conjugates to and regulates the biological function of its substrates. The main target of NEDD8 is cullin-RING E3 ligases. Upregulation of the neddylation pathway is closely associated with the progression of various tumors, and MLN4924, which inhibits NEDD8-activating enzyme (NAE), is a promising new antitumor compound for combination therapy. Here, we summarize the latest progress in anticancer strategies targeting the neddylation pathway and their combined applications, providing a theoretical reference for developing antitumor drugs and combination therapies.

SUBMITTER: Gai W

PROVIDER: S-EPMC8060460 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Advances in Cancer Treatment by Targeting the Neddylation Pathway.

Gai Wenbin W Peng Zhiqiang Z Liu Cui Hua CH Zhang Lingqiang L Jiang Hong H

Frontiers in cell and developmental biology 20210408

Developmental down-regulation protein 8 (NEDD8), expressed by neural progenitors, is a ubiquitin-like protein that conjugates to and regulates the biological function of its substrates. The main target of NEDD8 is cullin-RING E3 ligases. Upregulation of the neddylation pathway is closely associated with the progression of various tumors, and MLN4924, which inhibits NEDD8-activating enzyme (NAE), is a promising new antitumor compound for combination therapy. Here, we summarize the latest progress ...[more]

PMID: 33898451

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