Dataset Information

Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution.

ABSTRACT: The effective pulmonary deposition of inhaled particulate carriers loaded with drugs is a prerequisite for therapeutic effects of drug delivery via inhalation route. Revealing the sophisticated lung scaffold and intrapulmonary distribution of particles at three-dimensional (3D), in-situ, and single-particle level remains a fundamental and critical challenge for dry powder inhalation in pre-clinical research. Here, taking advantage of the micro optical sectioning tomography system, the high-precision cross-scale visualization of entire lung anatomy is obtained. Then, co-localized lung-wide datasets of both cyto-architectures and fluorescent particles are collected at full scale with the resolution down to individual particles. The precise spatial distribution pattern reveals the region-specific distribution and structure-associated deposition of the inhalable particles in lungs, which is undetected by previous methods. Overall, this research delivers comprehensive and high-resolution 3D detection of pulmonary drug delivery vectors and provides a novel strategy to evaluate materials distribution for drug delivery.

SUBMITTER: Sun X

PROVIDER: S-EPMC8061354 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution.

Sun Xian X Zhang Xiaochuan X Ren Xiaohong X Sun Hongyu H Wu Li L Wang Caifen C Ye Xiaohui X York Peter P Gao Zhaobing Z Jiang Hualiang H Zhang Jiwen J Yin Xianzhen X

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20210208 8

The effective pulmonary deposition of inhaled particulate carriers loaded with drugs is a prerequisite for therapeutic effects of drug delivery via inhalation route. Revealing the sophisticated lung scaffold and intrapulmonary distribution of particles at three-dimensional (3D), in-situ, and single-particle level remains a fundamental and critical challenge for dry powder inhalation in pre-clinical research. Here, taking advantage of the micro optical sectioning tomography system, the high-preci ...[more]

PMID: 33898181

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Dataset Information

Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution.

Publications

Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution.

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