Dataset Information

Post-hoc physiological waveform extraction from motion estimation in simultaneous multislice (SMS) functional MRI using separate stack processing.

ABSTRACT:

Purpose

Motion estimation is an essential step in functional MRI (fMRI) preprocessing. Usually, fMRI processing software packages (eg, FSL and AFNI) automatically estimate motion parameters in order to counteract the effects of motion. However, the time courses of the motion estimation for fMRI data also contain information about physiological processes. Here, we show that respiration and cardiac signals can be extracted from motion estimation at significantly higher bandwidth than is possible with current methods.

Method

To detect motion at high effective temporal resolution (HighRes), the motion parameters of stacks of simultaneously acquired slices were estimated separately, then combined. This method was validated by extracting physiological motion signals from resting state fMRI (rsfMRI) data (Enhanced Nathan Kline Institute-Rockland Sample) and comparing them to respiration belt and pulse oximeter signals.

Results

HighRes motion time-courses with an effective sampling rate of 15.5 and 11.4 Hz were extracted from repetition time (TR) = 0.645 and 1.4 s data, respectively. Respiration waveforms were extracted with significantly higher accuracy than the original motion parameters. Even cardiac waveforms could be extracted, despite the fact that the sampling time or TR values were too long to sample cardiac frequencies.

Conclusion

HighRes motion traces provide insight into the subjects' motion at higher frequencies than can be estimated using standard techniques. In its simplest form, this technique can recover accurate respiration signals and may reveal additional complexity in brain motion.

SUBMITTER: Hocke LM

PROVIDER: S-EPMC8061789 | biostudies-literature |

REPOSITORIES: biostudies-literature

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