Peroxiredoxin alleviates the fitness costs of imidacloprid resistance in an insect pest of rice.

ABSTRACT: Chemical insecticides have been heavily employed as the most effective measure for control of agricultural and medical pests, but evolution of resistance by pests threatens the sustainability of this approach. Resistance-conferring mutations sometimes impose fitness costs, which may drive subsequent evolution of compensatory modifier mutations alleviating the costs of resistance. However, how modifier mutations evolve and function to overcome the fitness cost of resistance still remains unknown. Here we show that overexpression of P450s not only confers imidacloprid resistance in the brown planthopper, Nilaparvata lugens, the most voracious pest of rice, but also leads to elevated production of reactive oxygen species (ROS) through metabolism of imidacloprid and host plant compounds. The i

SUBMITTER: Pang R 

PROVIDER: S-EPMC8062100 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature