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Novel and emerging mutations of SARS-CoV-2: Biomedical implications.

ABSTRACT: Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus strains has geographical diversity associated with diverse severity, mortality rate, and response to treatment that were characterized using phylogenetic network analysis of SARS-CoV-2 genomes. Although, there is no explicit and integrative explanation for these variations, the genetic arrangement, and stability of SARS-CoV-2 are basic contributing factors to its virulence and pathogenesis. Hence, understanding these features can be used to predict the future transmission dynamics of SARS-CoV-2 infection, drug development, and vaccine. In this review, we discuss the most recent findings on the mutations in the SARS-CoV-2, which provide valuable information on the genetic diversity of SARS-CoV-2, especially for DNA-based diagnosis, antivirals, and vaccine development for COVID-19.

SUBMITTER: Mohammadi E 

PROVIDER: S-EPMC8062574 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Novel and emerging mutations of SARS-CoV-2: Biomedical implications.

Mohammadi Elmira E   Shafiee Fatemeh F   Shahzamani Kiana K   Ranjbar Mohammad Mehdi MM   Alibakhshi Abbas A   Ahangarzadeh Shahrzad S   Beikmohammadi Leila L   Shariati Laleh L   Hooshmandi Soodeh S   Ataei Behrooz B   Javanmard Shaghayegh Haghjooy SH  

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20210423

Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus strains has geographical diversity associated with diverse severity, mortality rate, and response to treatment that were characterized using phylogenetic network analysis of SARS-CoV-2 genomes. Although, there is no explicit and integrative explanation for these variations, the genetic arrangement, and stability of SARS-CoV-2 are basic contributing factors to its viru  ...[more]

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