Ontology highlight
ABSTRACT:
SUBMITTER: Bashir A
PROVIDER: S-EPMC8062585 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Bashir Ali A Yang Qin Q Wang Jinpeng J Hoyer Stephan S Chou Wenchuan W McLean Cory C Davis Geoff G Gong Qiang Q Armstrong Zan Z Jang Junghoon J Kang Hui H Pawlosky Annalisa A Scott Alexander A Dahl George E GE Berndl Marc M Dimon Michelle M Ferguson B Scott BS
Nature communications 20210422 1
Aptamers are single-stranded nucleic acid ligands that bind to target molecules with high affinity and specificity. They are typically discovered by searching large libraries for sequences with desirable binding properties. These libraries, however, are practically constrained to a fraction of the theoretical sequence space. Machine learning provides an opportunity to intelligently navigate this space to identify high-performing aptamers. Here, we propose an approach that employs particle displa ...[more]