Tetra-arylborate lipophilic anions as targeting groups.
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ABSTRACT: Tetraphenylborate (TPB) anions traverse membranes but are excluded from mitochondria by the membrane potential (Δψ). TPB-conjugates also distributed across membranes in response to Δψ, but surprisingly, they rapidly entered cells. They accumulated within lysosomes following endocystosis. This pH-independent targeting of lysosomes makes possible new classes of probe and bioactive molecules.
SUBMITTER: Gaddale Devanna KK
PROVIDER: S-EPMC8062962 | biostudies-literature |
REPOSITORIES: biostudies-literature
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