Effect of Dapagliflozin on Urine Metabolome in Patients with Type 2 Diabetes.

ABSTRACT:

Context

Inhibitors of sodium-glucose cotransporters-2 have cardio- and renoprotective properties. However, the underlying mechanisms remain indeterminate.

Objective

To evaluate the effect of dapagliflozin on renal metabolism assessed by urine metabolome analysis in patients with type 2 diabetes.

Design

Prospective cohort study.

Setting

Outpatient diabetes clinic of a tertiary academic center.

Patients

Eighty patients with hemoglobin A1c > 7% on metformin monotherapy were prospectively enrolled.

Intervention

Fifty patients were treated with dapagliflozin for 3 months. To exclude that the changes observed in urine metabolome were merely the result of the improvement in glycemia, 30 patients treated with insulin degludec were used for comparison.

SUBMITTER: Bletsa E 

PROVIDER: S-EPMC8063232 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature